Extracellular histones promote thrombin generation through platelet- dependent mechanisms: involvement of platelet TLR2 and 4
نویسندگان
چکیده
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. Department of Biochemistry, University of Illinois at UrbanaChampaign, Urbana, IL, USA. College of Medicine, University of Illinois at UrbanaChampaign, Urbana, IL, USA. Department of Medicine, University of Oklahoma Health Sciences Center, OK, USA. Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. 6 Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Howard Hughes Medical Institute, OK, USA.
منابع مشابه
Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4.
The release of histones from dying cells is associated with microvascular thrombosis and, because histones activate platelets, this could represent a possible pathogenic mechanism. In the present study, we assessed the influence of histones on the procoagulant potential of human platelets in platelet-rich plasma (PRP) and in purified systems. Histones dose-dependently enhanced thrombin generati...
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تاریخ انتشار 2011